Dermatoscopic findings of penile intraepithelial neoplasia. It is a premalignant dermatosis that usually occurs on the glans penis and appears as a wellmarginated erythematous velvety patch or plaque. Basal cell carcinoma of the penis is usually located along the penile shaft. A clinicopathologic and histochemical study graham, james h helwig, elson b. Depending upon the context, this term may refer specifically to carcinoma in situ of the glans penis or vulva appearing as a red patch, or may be used as a synonym of erythroplasia on other. Lesions can occasionally have a warty or crusty appearance. Methylaminolaevulinic acid photodynamic therapy in the treatment of erythroplasia of queyrat. A premalignant condition morphologically characterised by the presence of the characteristic pagets cells in the intraepithelial tissue of the penis.
Because of the color and the infiltration, and by comparison with leukoplakia in its tendency to become malignant, queyrat proposed the name, erythroplasie du gland. Erythroplasia of queyrat may also occur on the anal mucosa or the oral mucosa. The clinical appearance is that of a sharply demarcated, erythematous plaque that is persistent and slowly enlarging. Squamous cell carcinoma in situ on the mucosal or transitional surfaces is also referred to as erythroplasia of queyrat eq. Penile preservation surgery in a case of erythroplasia of. Erythroplasia of queyrat deirdre mary fanning, hugh flood department of urology, midwestern regional hospital, dooradoyle, limerick, co. There are several noninvasive treatment options for erythroplasia of queyrat such as photodynamic therapy, cryosurgery and applying various kinds of topical agents. Conejomir js, munoz ma, linares m, rodriguez l, serrano a. A case of erythroplasia of queyrat treated with imiquimod. A biopsy with subsequent histopathological examination is. Another french author, queyrat, 4 in 1911 devoted himself to a more exhaustive study of the condition and gave it the name of erythroplasie.
In the region, one third of penile squamous cell carcinoma in situ cases progress to invasive squamous cell carci noma. Nov 07, 2019 erythroplasia of queyrat eq is an in situ squamous cell carcinoma of the penis. Keywords erythroplasia of queyrat, zoons balanitis, balanoposthitis. Limerick, ireland abstract a 58yearold caucasian male presented to the urology clinic reporting an approximate oneyear history of a persistent irritating, slowly progressive, glans penis redness.
Risk factors for the development of bowens disease and eq vary according to the. Erythroplasia of queyrat is a squamouscell carcinoma in situ of the glans penis head of the penis or inner prepuce foreskin in males, and the vulvae in females. At a later date 1911, queyrat 2 described in detail several cases of what was apparently an identical condition. Department of dermatology, university of tsukuba, tsukuba, japan.
Positive results were obtained after 4 weeks of topical application of 5% imiquimod cream, once daily, 5 times a week. Human papillomavirus type 16 dna has previously been detected only in very few distinctly characterized patients. Erythroplasia of queyrat is a term used to describe a rare premalignant lesion of penile in situ squamous cell carcinoma. Single or multiple, nontender, red, shiny patches or plaques of the mucosal penis ie the glans and prepuce of the uncircumcised. Erythroplasia of queyrat uf health, university of florida. The skin sometimes turns puffy and might crack and split. Pdf erythroplasia of queyrat treated with topical 5. Blau and hyman erythroplasia of queyrat is similar to bowens disease of the skin.
The cancer is called squamous cell carcinoma in situ. Erythroplasia definition of erythroplasia by medical dictionary. Erythroplakia is a clinical term to describe any erythematous red area on a mucous membrane, that cannot be attributed to any other pathology 805 the term erythroplasia was coined by louis queyrat to describe a precancerous red lesion of the penis. The topic erythroplasia of queyrat you are seeking is a synonym, or alternative name, or is closely related to the medical condition squamous cell carcinoma in situ of penis. Erythroplasia of queyrat treated with 5% imiquimod cream. Histopathology peniserythroplasia of queyrat youtube. Bowenoid papulosis, bowen disease and erythroplasia of queyrat. Erythroplasia of queyrat was originally described by tarnovsky in 1891 and later appreciated as a penile disease by fournier and darier in 1893. Introduction erytroplasia queyrat eq is a rare disease which arises from the squamous epithelial cells of the glans penis or inner lining of the prepuce. Clinically, erythroplasia of queyrat appears as red velvety moist smooth plaques and is most common in uncircumcised men over age 40. Pdf a case of erythroplasia of queyrat treated with imiquimod 5. The cause of erythroplasia of queyrat is largely unknown.
A biopsy with subsequent histopathological examination is necessary to. Zoons balanitis, penile intraepithelial neoplasiacarcinoma in situerythroplasia of queyrat eq, squamous cell cancer of the penis, malignant melanoma of the penis and rarely basal cell cancer of the penis. This term is used only when the cancer occurs on the penis. This gave rise to the term erythoplasia of queyrat. Erythroplasia of queyrat is an early form of skin cancer found on the penis.
Erythroplasia of queyrat description of erythroplasia of queyrat. Studies by queyrat in 1911 allowed erythroplasia of queyrat to be accepted as a distinct entity. Squamous cell cancer in situ can occur on any part of the body. May 29, 2012 differential diagnosis included balanitis example. Tarnovsky originally described erythroplasia of queyrat in 1891, but it was queyrat who coined the term erythroplasia in 1911. Erythroplasia of queyrat an overview sciencedirect topics.
May 01, 2020 erythroplasia of queyrat is a type of skin cancer of the penis, seen most commonly in men who are not circumcised. Other names for penile intraepithelial neoplasia include. Is distinction between erythroplasia of queyrat and. Men who have erythroplasia of queyrat might initially notice redness and irritation before discolored lesions develop. Darier accepted this new name, and the disease is now generally known as the erythroplasie, erythroplasia, erythroplakie or erythroplakia of queyrat. Bowens disease of the penis bdp red or occasionally hyperpigmented scaly patches and plaques of the keratinised penis. Positive results were obtained after 4 weeks of topical application of 5% imiquimod cream, once daily, 5. We describe the case of a 68 years old patient, with clinical and histological diagnosis of erythroplasia of queyrat. A 58yearold caucasian male presented to the urology clinic reporting an approximate oneyear history of a persistent irritating, slowly progressive, glans penis redness. It is named for french dermatologist louis queyrat 18561933, who was head of the dermatology service of lhopital ricord, a venereal hospital in paris, now hopital cochin. Erythroplasia of queyrat bowen disease of the glans penis.
It resembles bowens disease and therefore the terms are frequently equated. Erythroplasia of queyrat definition erythroplasia of queyrat is an early form of skin cancer found on the penis. Zoons balanitis, penile intraepithelial neoplasiacarcinoma in situ erythroplasia of queyrat eq, squamous cell cancer of the penis, malignant melanoma of the penis and rarely basal cell cancer of the penis. Erythroplasia of queyrat and bowenoid papulosis primary. A case of erythroplasia of queyrat treated with imiquimod 5%. Erythroplasia of queyrat definition of erythroplasia of. It mainly occurs in uncircumcised males, over the age of 40. Bowens disease and erythroplasia of queyrat clinical gate. It usually is not aggressive but can become locally invasive, and it is advisable for a man who might have this condition to receive prompt treatment.
The glans is the predominant location of this lesion, and its nonspecific presentation a sharply defined red patch or plaque, may often lead to a misdiagnosis as one of many mucosal dermatoses. The premalignant lesions included were erythroplasia of queyrat. Squamous cell carcinoma in situ on the penile mucosa or transitional surfaces is also known as erythroplasia of queyrat. Erythroplasia of queyrat should be diagnosed in a noncompliant patient based on the clinical picture and hpv testing even in the absence of a biopsy, and a non.
Carbon dioxide laser treatment of erythroplasia of. Beier c, gregel c, kaufmann r 1998 topische photodynamische therapie mit 5. Erythroplasia of queyrat eq is an in situ squamous cell carcinoma of the penis. Erythroplasia of queyrat treated with imiquimod 5% cream. Erythroplasia of queyrat information mount sinai new york. Erythroplasia of queyrat is caused by high risk hpv types 16,18,31,35. Selected cases of eq have been treated successfully using 5fluorouracil. Also, mohs micrographic surgery has been used in the treatment of erythroplasia of queyrat. Circumcision at an early age is thought to prevent its development. Bowens disease of the glans penis erythroplasia of queyrat in plasma cell balanitis. It is also known as bowens disease of the penis and can be. Erythroplasia of queyrat is a carcinoma in situ of the mucosa and the transitional epithelia.
Feldmeyer l, krauszenderlin v, tondury b, hafner j, french le, hofbauer gf. Development of squamous cell carcinoma from erythroplasia. Erythroplasia of queyrat penn state hershey medical center. Methods employed include cryotherapy, laser ablation, and surgical excision. It is reported to occur in the corneoscleral limbus. Given the size and location of the lesion, preventing the surgical option, we performed the treatment with co2 laser. The term erythroplasia was coined by louis queyrat to describe a precancerous red lesion of the penis. A clinical diagnosis of erythroplasia of queyrat was established and the test for hpv revealed an association with subtype 16 which excluded other benign inflammatory conditions. The condition is most often seen in men who have not been circumcised. This article describes the construction and use of an yttrium 90 applicator in the treatment of a patient with queyrats erythroplasia, or bowens disease, of the glans penis blau and hyman, 1955.
Bowens disease and erythroplasia of queyrat plastic. Erythroplasia of queyrat has a higher tendency to become invasive in comparison to non genital squamous cell cancer in situ. Squamous cell carcinoma in situ of penis is a malignant condition affecting the skin or mucosal membranes of the penis. Penile preservation surgery in a case of erythroplasia of queyrat involving the glans penis and distal urethra. Erythroplasia of the glans penis queyrat jama dermatology. Erythroplasia of queyrat is a rare in situ carcinoma of the uncircumcised man and its treatment depends on the extent and location of the lesion. Bowens disease and erythroplasia of queyrat eq are defined as intraepidermal squamous cell carcinoma, the latter occurring on the penis. Erythroplasia of queyrat treated with topical methyl aminolevulinate photodynamic therapy. This condition is a form of squamous cell carcinoma that develops in the upper cells of the epithelium.
A clinicopathologic and histochemical study erythroplasia of queyrat. Erythroplasia of queyrat is a clinical expression of carcinoma in situ of the penis. Queyrats erythroplasia of the penis treated by beta. Erythroplasia of queyrat scc in situ of the glans or prepuce in males, m. Depending upon the context, this term may refer specifically to carcinoma in situ of. Erythroplasia of queyrat jama dermatology jama network. Pdf a 58yearold caucasian male presented to the urology clinic reporting an. Penile intraepithelial neoplasia is a rare precancerous disease of the outer skin layer epidermis of the penis. Progression to invasive carcinoma may occur, and spontaneous regression is unlikely. It presents as a smooth raised reddish area that may or may not be painful. Treatment of erythroplasia of queyrat often involves removal or destruction of the lesion. The condition is typically found in men who have not had the foreskin of the penis surgically removed circumcision. In 1933, sulzberger and satenstein recognized erythroplasia of queyrat as a form of carcinoma in situ.
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